The college operates under a formal Academic Policies and Procedures Manual covering student conduct, classroom rules, library usage, laboratory procedures, and other institutional regulations that students agree to follow upon admission.

A defined disciplinary sanctions framework exists outlining conduct expectations and penalties, including warnings, suspension, and expulsion. The Dean serves as the ultimate authority, with provisions available for hearings and due process.

The college is affiliated with Dr. NTR University of Health Sciences, Vijayawada, and adheres to the University's statutes relating to curriculum, examinations, intake capacity, and admission procedures for MBBS and postgraduate programmes.

As a medical institution, the college complies with Medical Council/NMC regulations governing medical education norms, faculty requirements, hospital standards, and student training through affiliation requirements enforced by the University and NMC.

The college and its teaching hospital follow operational norms, including emergency services, patient care standards, and access to institutional facilities as outlined in the Citizen Charter.

Internal best-practice initiatives, such as the Village Health Adoption Scheme, reflect the institution's commitment to community engagement and experiential learning opportunities for students.